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In people with CF, a defective gene causes a thick, sticky buildup of mucus in the lungs, pancreas, and other organs.

In the lungs, the mucus clogs the airways and traps bacteria leading to infections, extensive lung damage, and eventually, respiratory failure.

Their parents will not usually have the condition themselves, because they will only carry one faulty gene and one that works normally.

Cystic fibrosis is an inherited condition in which the lungs and digestive system can become clogged with thick, sticky mucus.

This network of pooled talent, with funding from the CF Foundation, contributed to the original discovery of the CF gene in 1989 -- the single most important discovery in CF research.

In the late 1990s, the CF Foundation established key programs to help speed development of CF therapies, including a national network of centers designed to conduct clinical trials and share data, and a therapeutics development program to support and govern research collaborations with biotech and pharmaceutical companies.

Most cases of cystic fibrosis in the UK are now identified through screening tests carried out soon after birth.

It's estimated that 1 in every 2,500 babies born in the UK has cystic fibrosis.

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